SrasV1, Main, Exploration, bibRecord, 003696

Heparan sulfate is a binding molecule but not a receptor for CEACAM1-independent infection of murine coronavirus.

Identifieur interne : 003696 ( Main/Exploration ); précédent : 003695; suivant : 003697

Heparan sulfate is a binding molecule but not a receptor for CEACAM1-independent infection of murine coronavirus.

Auteurs : Rie Watanabe [Japon] ; Stanley G. Sawicki ; Fumihiro Taguchi

Source :

Virology [ 0042-6822 ] ; 2007.

RBID : pubmed:17692355

Descripteurs français

KwdFr :
- Animaux, Antigène carcinoembryonnaire (physiologie), Coronavirus (), Coronavirus (pathogénicité), Coronavirus (physiologie), Cricetinae, Héparitine sulfate (métabolisme), Infections à coronavirus (physiopathologie), Liaison aux protéines, Lignée cellulaire, Membrane cellulaire (virologie), Rein, Récepteurs viraux (physiologie), Sites de fixation, Souris, Séquence d'acides aminés, Virulence.
MESH :
- métabolisme : Héparitine sulfate.
- pathogénicité : Coronavirus.
- physiologie : Antigène carcinoembryonnaire, Coronavirus, Récepteurs viraux.
- physiopathologie : Infections à coronavirus.
- virologie : Membrane cellulaire.
- Animaux, Coronavirus, Cricetinae, Liaison aux protéines, Lignée cellulaire, Rein, Sites de fixation, Souris, Séquence d'acides aminés, Virulence.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Binding Sites, Carcinoembryonic Antigen (physiology), Cell Line, Cell Membrane (virology), Coronavirus (classification), Coronavirus (pathogenicity), Coronavirus (physiology), Coronavirus Infections (physiopathology), Cricetinae, Heparitin Sulfate (metabolism), Kidney, Mice, Protein Binding, Receptors, Virus (physiology), Virulence.
MESH :
- chemical , metabolism : Heparitin Sulfate.
- chemical , physiology : Carcinoembryonic Antigen, Receptors, Virus.
- classification : Coronavirus.
- pathogenicity : Coronavirus.
- physiology : Coronavirus.
- physiopathology : Coronavirus Infections.
- virology : Cell Membrane.
- Amino Acid Sequence, Animals, Binding Sites, Cell Line, Cricetinae, Kidney, Mice, Protein Binding, Virulence.

Abstract

A highly neurovirulent mouse hepatitis virus (MHV) JHMV strain (wt) with receptor (MHVR)-independent infection activity and its low-virulent mutant srr7 without such activity were found to attach to MHVR-negative, non-permissive BHK cells. To identify the molecule that interacts with JHMV, we focused on heparan sulfate (HS) since it works as a receptor of a mutant MHV-rec1 that infects in an MHVR-independent fashion. The present study indicates that HS interacts with both wt JHMV and srr7 but it does not function as an entry receptor as it apparently does for MHV-rec1. Furthermore, HS failed to serve as an entry receptor in the MHVR-independent infection of wt JHMV, indicating that HS is not a host factor that wt JHMV utilizes in an MHVR-independent infection.

DOI: 10.1016/j.virol.2007.06.034
PubMed: 17692355

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">A highly neurovirulent mouse hepatitis virus (MHV) JHMV strain (wt) with receptor (MHVR)-independent infection activity and its low-virulent mutant srr7 without such activity were found to attach to MHVR-negative, non-permissive BHK cells. To identify the molecule that interacts with JHMV, we focused on heparan sulfate (HS) since it works as a receptor of a mutant MHV-rec1 that infects in an MHVR-independent fashion. The present study indicates that HS interacts with both wt JHMV and srr7 but it does not function as an entry receptor as it apparently does for MHV-rec1. Furthermore, HS failed to serve as an entry receptor in the MHVR-independent infection of wt JHMV, indicating that HS is not a host factor that wt JHMV utilizes in an MHVR-independent infection.</div>
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Serveur d'exploration SRAS

Heparan sulfate is a binding molecule but not a receptor for CEACAM1-independent infection of murine coronavirus.

Heparan sulfate is a binding molecule but not a receptor for CEACAM1-independent infection of murine coronavirus.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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